A case of an 11-year-old girl diagnosed with OCD developing giggle incontinence following addition of aripiprazole to treatment

A case of an 11-year-old girl diagnosed with OCD developing giggle incontinence following addition of aripiprazole to treatment

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Giggle incontinence (GI) is characterized by involuntary and generally unpredictable release of urine during giggling or laughter.It has been suggested that GI may be a centrally mediated disorder and may share a common pathophysiology with narcolepsy STEP BARS and cataplexy.The fact that methylphenidate reduces some symptoms suggests that the condition may be a cataplexy.

While alpha 1 and dopamine D2 antagonists exacerbate cataplexy, alpha 1 and APPLE SAUCE ORG dopamine D2 agonists produce a marked improvement.Aripiprazole, frequently used to augment treatment of obsessive compulsive disorder, may have exhibited an alpha 1 and D2 receptor antagonist effect and have caused GI.We describe a case of GI occurring following aripiprazole use in an 11-year-old female obsessive compulsive disorder patient resistant to treatment.